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Nervous System Diseases > Central Nervous System Diseases > Brain Diseases > Basal Ganglia Diseases > Neuroleptic Malignant Syndrome
Chemically-Induced Disorders > Poisoning > Neurotoxicity Syndromes > Neuroleptic Malignant Syndrome
Nervous System Diseases > Neurotoxicity Syndromes > Neuroleptic Malignant Syndrome

Preferred term

Neuroleptic Malignant Syndrome  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • NMS (Neuroleptic Malignant Syndrome)
  • NMSs (Neuroleptic Malignant Syndrome)

Note

  • caused by tranquilizing agents so do not use /chem ind

Scope note

  • A potentially fatal syndrome associated primarily with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS) which are in turn associated with dopaminergic receptor blockade (see RECEPTORS, DOPAMINE) in the BASAL GANGLIA and HYPOTHALAMUS, and sympathetic dysregulation. Clinical features include diffuse MUSCLE RIGIDITY; TREMOR; high FEVER; diaphoresis; labile blood pressure; cognitive dysfunction; and autonomic disturbances. Serum CPK level elevation and a leukocytosis may also be present. (From Adams et al., Principles of Neurology, 6th ed, p1199; Psychiatr Serv 1998 Sep;49(9):1163-72)

History note

  • 1986(1985)

In other languages

  • neuroleptioireyhtymä

    Finnish

  • maligni neuroleptioireyhtymä
  • maligni neuroleptisyndrooma
  • malignt neuroleptikasyndrom
  • neuroleptisyndrooma
  • pahanlaatuinen neuroleptioireyhtymä
  • pahanlaatuinen neuroleptisyndrooma
  • syndroma neurolepticum malignum
  • Neuroleptiskt malignt syndrom

    Swedish

URI

http://www.yso.fi/onto/mesh/D009459

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