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... > Chemical Actions and Uses > Pharmacologic Actions > Physiological Effects of Drugs > Hormones, Hormone Substitutes, and Hormone Antagonists > Hormones > Thyroid Hormones > Thyroxine
Amino Acids, Peptides, and Proteins > Amino Acids > Amino Acids, Cyclic > Amino Acids, Aromatic > Thyroxine

Preferred term

Thyroxine  

Type

  • Topical Descriptor

Broader concept

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Entry terms

  • 3,5,3',5'-Tetraiodothyronine
  • O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodotyrosine
  • T4 Thyroid Hormone
  • Thyroid Hormone, T4
  • Thyroxin

Note

  • /blood: consider also HYPERTHYROXINEMIA

Scope note

  • The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism.

History note

  • 1965; use THYROXIN 1963-1964; for LEVOTHYROXINE use LEVOTHYROXINE 1991-2001, use THYROXINE 1966-1990

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URI

http://www.yso.fi/onto/mesh/D013974

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