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... > Chemical Phenomena > Biochemical Phenomena > Molecular Structure > Molecular Conformation > Protein Conformation > Protein Structural Elements > Protein Domains > C2 Domains
... > Chemical Phenomena > Biochemical Phenomena > Molecular Structure > Molecular Conformation > Protein Conformation > Protein Structure, Tertiary > Protein Domains > C2 Domains

Preferred term

C2 Domains  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • C2 Domain

Scope note

  • Protein modules that function in the targeting of proteins to CELL MEMBRANES. They consist of an eight-stranded anti-parallel beta-sandwich composed of a pair of four-stranded beta-sheets. This structural unit forms a pocket on the membrane-interacting face of the protein and co-ordinates the binding of 2 to 3 calcium ions; however, not all C2 domains bind calcium. Examples of C2 domain-containing proteins include PROTEIN KINASE C and PTEN PHOSPHOHYDROLASE.

History note

  • 2017

In other languages

URI

http://www.yso.fi/onto/mesh/D000070538

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