Concept information
Preferred term
Perilipin-2
Type
-
Topical Descriptor
Broader concept
Entry terms
- Adipophilin
- Adipose Differentiation Related Protein
- Adipose Differentiation-Related Protein
- ADRP Protein
- Perilipin 2 Protein
- PLIN2 Protein
- Protein, Adipose Differentiation-Related
- Protein, Perilipin 2
- Protein, PLIN2
Scope note
- A perilipin that is expressed by many different cell types. It binds FATTY ACIDS and CHOLESTEROL, stabilizes TRIGLYCERIDES, and localizes to both the surface and hydrophobic core of LIPID DROPLETS, as well as the ENDOPLASMIC RECTICULUM and PLASMA MEMBRANE in MACROPHAGES. It also plays a central role in the biogenesis of lipid droplets and FOAM CELLS and is highly expressed by macrophages at atherosclerotic lesions in human arteries along with the INFLAMMATION markers TNF-ALPHA; MCP-1 RECEPTOR; and IL-6.
History note
- 2017 (1998)
In other languages
-
Finnish
-
Swedish
-
Perilin-2-protein
-
PLIN2 protein
URI
http://www.yso.fi/onto/mesh/D000070780
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