Concept information
Preferred term
MutL Proteins
Type
-
Topical Descriptor
Broader concept
Narrower concepts
Entry terms
- MutL Homologs
Scope note
- DNA repair proteins that include the bacterial MutL protein and its eukaryotic homologs. They consist of a conserved N-terminal region with weak ATPase activity, an endonuclease motif, and a C-terminal domain that forms MutL homodimers or heterodimers between MLH1 and the PMS1, MISMATCH REPAIR ENDONUCLEASE PMS2; or MLH3 proteins. These complexes function in DNA repair pathways, primarily DNA MISMATCH REPAIR, where MutL/MLH1 and the MUTS DNA MISMATCH-BINDING PROTEIN are targeted to damaged DNA.
History note
- 2017
In other languages
-
Finnish
URI
http://www.yso.fi/onto/mesh/D000070956
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