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Enzymes and Coenzymes > Enzymes > DNA Repair Enzymes > MutL Proteins > MutL Protein Homolog 1
Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > MutL Proteins > MutL Protein Homolog 1
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Acid Anhydride Hydrolases > Adenosine Triphosphatases > MutL Proteins > MutL Protein Homolog 1

Preferred term

MutL Protein Homolog 1  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • COCA2 Protein
  • Colon Cancer, Nonpolyposis Type 2 Protein
  • MLH1 Protein
  • MutL Homolog 1

Scope note

  • Eukaryotic homolog of the bacterial MutL DNA MISMATCH REPAIR protein. It heterodimerizes with MISMATCH REPAIR ENDONUCLEASE PMS2 to form MutL alpha, which is recruited to DNA mismatch sites by the MUTS DNA MISMATCH-BINDING PROTEIN. Mutations in the human MLH1 gene are associated with COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS.

History note

  • 2017

In other languages

URI

http://www.yso.fi/onto/mesh/D000070957

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