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... > Amino Acids, Peptides, and Proteins > Proteins > Scleroproteins > Extracellular Matrix Proteins > ADAMTS Proteins > ADAMTS13 Protein
... > Amino Acids, Peptides, and Proteins > Proteins > Glycoproteins > ADAM Proteins > ADAMTS Proteins > ADAMTS13 Protein
... > Carbohydrates > Glycoconjugates > Glycoproteins > ADAM Proteins > ADAMTS Proteins > ADAMTS13 Protein
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Endopeptidases > Metalloendopeptidases > ADAM Proteins > ADAMTS Proteins > ADAMTS13 Protein
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Metalloproteases > Metalloendopeptidases > ADAM Proteins > ADAMTS Proteins > ADAMTS13 Protein

Preferred term

ADAMTS13 Protein  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • ADAMTS13 Protease
  • ADAMTS 13 Protein
  • ADAMTS-13 Protein
  • A Disintegrin and Metalloproteinase with Thrombospondin Motifs 13 Protein
  • von Willebrand Factor Cleaving Protease
  • von Willebrand Factor-Cleaving Protease
  • vWF Cleaving Protease
  • vWF-Cleaving Protease

Scope note

  • An ADAMTS protease that contains eight thrombospondin (TS) motifs. It cleaves VON WILLEBRAND FACTOR to control vWF-mediated THROMBOSIS. Mutations in the ADAMTS13 gene have been identified in familial cases of PURPURA, THROMBOTIC THROMBOCYTOPENIC and defects in ADAMTS13 activity are associated with MYOCARDIAL INFARCTION; BRAIN ISCHEMIA; PRE-ECLAMPSIA; and MALARIA.

History note

  • 2017

In other languages

URI

http://www.yso.fi/onto/mesh/D000071120

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