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Amino Acids, Peptides, and Proteins > Proteins > Parkinson Disease Associated Proteins > Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Protein Serine-Threonine Kinases > Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Protein Serine-Threonine Kinases > Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
... > Enzymes and Coenzymes > Enzymes > Transferases > Phosphotransferases > Phosphotransferases (Alcohol Group Acceptor) > Protein Kinases > Protein Serine-Threonine Kinases > Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Preferred term

Leucine-Rich Repeat Serine-Threonine Protein Kinase-2  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Dardarin Protein
  • LRRK2 Protein
  • PARK8 Protein

Scope note

  • A serine/threonine protein kinase with GTPase activity that contains 12 LEUCINE-rich repeats in its central region and 7 WD repeats C-terminal to its kinase and GTPase domains. It localizes to TRANSPORT VESICLES; the OUTER MITOCHONDRIAL MEMBRANE; and the GOLGI APPARATUS. It functions in PROTEIN TRANSPORT; regulates neuron morphology in the central nervous system, and also functions in the trafficking of SYNAPTIC VESICLES. Mutations in the LRRK2 gene have been identified in autosomal dominant cases of PARKINSON DISEASE (PARK8).

History note

  • 2017

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URI

http://www.yso.fi/onto/mesh/D000071158

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