Skip to main content

Medical Subject Headings

Search from vocabulary

Content language

Concept information

... > Amino Acids, Peptides, and Proteins > Proteins > Transcription Factors > Winged-Helix Transcription Factors > Forkhead Transcription Factors > Forkhead Box Protein O1
... > Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > Winged-Helix Transcription Factors > Forkhead Transcription Factors > Forkhead Box Protein O1

Preferred term

Forkhead Box Protein O1  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Forkhead in Rhabdomyosarcoma Protein
  • FOXO1 Protein

Scope note

  • A forkhead box transcription factor that is a major target of INSULIN signaling and regulator of metabolic homeostasis in response to OXIDATIVE STRESS. It binds to the insulin RESPONSE ELEMENT (IRE) and the related Daf-16 family binding element (DBE). Its activity is suppressed by insulin and it also regulates OSTEOBLAST proliferation, controls bone mass, and skeletal regulation of GLUCOSE metabolism. It promotes GLUCONEOGENESIS in HEPATOCYTES and regulates gene expression in ADIPOSE TISSUE. It is also an important CELL DEATH regulator. Chromosomal aberrations involving the FOXO1 gene occur in RHABDOMYOSARCOMA.

History note

  • 2017

In other languages

URI

http://www.yso.fi/onto/mesh/D000071161

Download this concept:

RDF/XML TURTLE JSON-LD Created 7/8/16, last modified 2/26/16