Skip to main content

Medical Subject Headings

Search from vocabulary

Content language

Concept information

Amino Acids, Peptides, and Proteins > Proteins > Cytoskeletal Proteins > Pyrin
Amino Acids, Peptides, and Proteins > Proteins > Tripartite Motif Proteins > Pyrin

Preferred term

Pyrin  

Type

  • Topical Descriptor

Broader concept

Related concepts

Entry terms

  • Marenostrin
  • Mediterranean Fever Protein
  • MEFV Protein
  • TRIM20 Protein

Scope note

  • A tripartite motif protein that consists of an N-terminal pyrin domain, a central coiled-coil region and B-box type ZINC FINGER, and C-terminal regions that mediate homotrimerization and interactions with other proteins (the B30.2/SPRY DOMAIN). It is expressed primarily by mature GRANULOCYTES and associates with the cytoskeleton in the perinuclear area as well as AUTOPHAGOSOMES, where it co-ordinates the assembly of AUTOPHAGY-RELATED PROTEINS and degradation of INFLAMMASOME components. It functions in INNATE IMMUNITY and INFLAMMATION; mutations in the Pyrin protein (MEFV) gene are associated with FAMILIAL MEDITERRANEAN FEVER.

History note

  • 2017 (1997)

In other languages

URI

http://www.yso.fi/onto/mesh/D000071198

Download this concept:

RDF/XML TURTLE JSON-LD Created 7/8/16, last modified 7/5/16