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Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > NLR Proteins > NLR Family, Pyrin Domain-Containing 3 Protein
Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > NLR Proteins > NLR Family, Pyrin Domain-Containing 3 Protein

Preferred term

NLR Family, Pyrin Domain-Containing 3 Protein  

Type

  • Topical Descriptor

Broader concept

Related concepts

Entry terms

  • Cold Autoinflammatory Syndrome 1 Protein
  • NACHT, LRR and PYD Domains Containing Protein 3
  • NACHT, LRR and PYD Domains-Containing Protein 3
  • NLRP3 Protein

Scope note

  • An NLR protein that contains an N-terminal PYRIN DOMAIN and ATP-binding site and 9 C-terminal LEUCINE-rich repeats; it is expressed primarily by MACROPHAGES. It is a core component of the INFLAMMASOME and directs its assembly in response to pathogen infection and damage-associated stimuli. Mutations in the NLRP3 gene are associated with FAMILIAL COLD AUTOINFLAMMATORY SYNDROME.

History note

  • 2017

In other languages

URI

http://www.yso.fi/onto/mesh/D000071199

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