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... > Enzymes and Coenzymes > Enzymes > Transferases > One-Carbon Group Transferases > Methyltransferases > Protein Methyltransferases > Histone Methyltransferases > Histone-Lysine N-Methyltransferase > Polycomb Repressive Complex 2 > Enhancer of Zeste Homolog 2 Protein
... > Amino Acids, Peptides, and Proteins > Proteins > Nuclear Proteins > Chromosomal Proteins, Non-Histone > Polycomb-Group Proteins > Polycomb Repressive Complex 2 > Enhancer of Zeste Homolog 2 Protein
... > Amino Acids, Peptides, and Proteins > Proteins > Nucleoproteins > Chromosomal Proteins, Non-Histone > Polycomb-Group Proteins > Polycomb Repressive Complex 2 > Enhancer of Zeste Homolog 2 Protein
Macromolecular Substances > Multiprotein Complexes > Polycomb-Group Proteins > Polycomb Repressive Complex 2 > Enhancer of Zeste Homolog 2 Protein
... > Amino Acids, Peptides, and Proteins > Proteins > Transcription Factors > Repressor Proteins > Polycomb-Group Proteins > Polycomb Repressive Complex 2 > Enhancer of Zeste Homolog 2 Protein
... > Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > Repressor Proteins > Polycomb-Group Proteins > Polycomb Repressive Complex 2 > Enhancer of Zeste Homolog 2 Protein

Preferred term

Enhancer of Zeste Homolog 2 Protein  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Enhancer of Zeste Homolog 2
  • EZH2, Histone-Lysine N-Methyltransferase
  • Histone Lysine N Methyltransferase EZH2
  • Histone-Lysine N-Methyltransferase EZH2
  • Lysine N Methyltransferase 6
  • Lysine N-Methyltransferase-6

Scope note

  • A histone-lysine N-methyltransferase and catalytic subunit of Polycomb Repressive Complex 2. It methylates LYSINE 9 (H3K9me) and LYSINE 27 (H3K27me) of HISTONE H3, leading to transcriptional repression of the affected target gene. EZH2 also methylates non-histone proteins such as GATA4 TRANSCRIPTION FACTOR and the nuclear receptor RORA. It regulates CIRCADIAN CLOCKS via histone methylation of circadian protein gene PROMOTER REGIONS, and its repressive activity is also important for the identity and differentiation of EMBRYONIC STEM CELLS.

History note

  • 2017 (2005)

In other languages

URI

http://www.yso.fi/onto/mesh/D000071221

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