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... > Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > Adaptor Proteins, Signal Transducing > Shc Signaling Adaptor Proteins > Src Homology 2 Domain-Containing, Transforming Protein 1
... > Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Adaptor Proteins, Signal Transducing > Shc Signaling Adaptor Proteins > Src Homology 2 Domain-Containing, Transforming Protein 1
... > Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Adaptor Proteins, Signal Transducing > Shc Signaling Adaptor Proteins > Src Homology 2 Domain-Containing, Transforming Protein 1

Preferred term

Src Homology 2 Domain-Containing, Transforming Protein 1  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • SHC1 Protein
  • SHC1 (Src Homology 2 Domain-Containing) Protein
  • ShcA Protein
  • SHC (Src Homology 2 Domain-Containing) Transforming Protein 1
  • SHC Transforming Protein 1
  • SHC-Transforming Protein 1
  • Src Homology 2 Domain Containing Transforming Protein C1
  • Src Homology 2 Domain-Containing-Transforming Protein C1

Scope note

  • An SHC-signaling adaptor protein that transduces PHOSPHOTYROSINE-dependent signals downstream of RECEPTOR PROTEIN-TYROSINE KINASES and non-receptor tyrosine kinases. It is required for TGF-BETA-induced CELL MIGRATION; NEOLPASM INVASION; and METASTASIS of BREAST NEOPLASMS; its SH2 DOMAIN is essential for tumor survival. It also functions in signaling downstream of ANGIOPOIETIN RECEPTOR TIE-2, regulating the migration of ENDOTHELIAL CELLS; and PHYSIOLOGIC NEOVASCULARIZATION.

History note

  • 2017; use SHC SIGNALING ADAPTOR PROTEINS 2009-2016

In other languages

URI

http://www.yso.fi/onto/mesh/D000071425

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