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... > Amino Acids, Peptides, and Proteins > Proteins > Transcription Factors > Basic-Leucine Zipper Transcription Factors > Basic Helix-Loop-Helix Leucine Zipper Transcription Factors > N-Myc Proto-Oncogene Protein
... > Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > Basic-Leucine Zipper Transcription Factors > Basic Helix-Loop-Helix Leucine Zipper Transcription Factors > N-Myc Proto-Oncogene Protein
... > Amino Acids, Peptides, and Proteins > Proteins > Transcription Factors > Basic Helix-Loop-Helix Transcription Factors > Basic Helix-Loop-Helix Leucine Zipper Transcription Factors > N-Myc Proto-Oncogene Protein
... > Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > Basic Helix-Loop-Helix Transcription Factors > Basic Helix-Loop-Helix Leucine Zipper Transcription Factors > N-Myc Proto-Oncogene Protein
... > Amino Acids, Peptides, and Proteins > Proteins > Neoplasm Proteins > Oncogene Proteins > Proto-Oncogene Proteins > N-Myc Proto-Oncogene Protein

Preferred term

N-Myc Proto-Oncogene Protein  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • BHLHE37 Protein
  • Class E Basic Helix Loop Helix Protein 37
  • Class E Basic Helix-Loop-Helix Protein 37
  • MYCN Protein
  • N Myc Protein
  • N-Myc Protein
  • NMYC Protein

Scope note

  • A basic helix-loop-helix leucine zipper (bHLHZ) transcription factor and proto-oncogene protein that functions in cell growth and proliferation. In mammals, it is highly expressed in the brain during embryogenesis and is essential for brain development; it is not expressed in adult tissues. Amplification or overexpression of N-Myc occurs in at least 20% of tumors and is associated with a poor prognosis in cases of NEUROBLASTOMA; ALVEOLAR RHABDOMYOSARCOMA; SMALL CELL LUNG CARCINOMA; and neuroendocrine prostate cancer.

History note

  • 2017

In other languages

URI

http://www.yso.fi/onto/mesh/D000071447

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