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Amino Acids, Peptides, and Proteins > Proteins > Autophagy-Related Proteins > Sequestosome-1 Protein
Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > Adaptor Proteins, Signal Transducing > Sequestosome-1 Protein
Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Adaptor Proteins, Signal Transducing > Sequestosome-1 Protein
Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Adaptor Proteins, Signal Transducing > Sequestosome-1 Protein

Preferred term

Sequestosome-1 Protein  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • EBI3 Associated Protein of 60 KDa
  • EBI3-Associated Protein of 60 KDa
  • EBIAP Protein
  • Phosphotyrosine Independent Ligand For The Lck SH2 Domain Of 62 Kda
  • Phosphotyrosine-Independent Ligand For The Lck SH2 Domain Of 62 Kda
  • Ubiquitin Binding Protein p62
  • Ubiquitin-Binding Protein p62

Scope note

  • A multidomain protein that is highly conserved among multicellular organisms. It contains a ZZ-type ZINC FINGER domain, C-terminal UBIQUITIN - associated (UBA) domain, and interacts with many other signaling proteins and enzymes including, atypical PROTEIN KINASE C; TNF RECEPTOR-ASSOCIATED FACTOR 6; subunits of the mTORC1 complex, and CASPASE-8. It functions in AUTOPHAGY as a receptor for the degradation of ubiquitinated substrates, and to co-ordinate signaling in response to OXIDATIVE STRESS.

History note

  • 2017

In other languages

URI

http://www.yso.fi/onto/mesh/D000071456

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RDF/XML TURTLE JSON-LD Created 7/8/16, last modified 4/15/16