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... > Enzymes and Coenzymes > Enzymes > Transferases > Phosphotransferases > Nucleotidyltransferases > RNA Nucleotidyltransferases > RNA Helicases > DEAD-box RNA Helicases > DEAD Box Protein 58

Preferred term

DEAD Box Protein 58  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 58
  • Probable ATP Dependent RNA Helicase DDX58
  • Probable ATP-Dependent RNA Helicase DDX58
  • RIG I like Receptor 1
  • RIG-I-like Receptor 1

Scope note

  • A DEAD-box RNA helicase that contains an N-terminal DEATH-LIKE DOMAIN, AAA+ ATPase domain, and C-terminal RNA HELICASE activity. It functions as an innate immune receptor through its recognition of viral nucleic acids. It also induces the expression of INTERFERON TYPE I and proinflammatory CYTOKINES. Its ligands include: 5'-triphosphorylated SINGLE-STRANDED RNA, DOUBLE-STRANDED RNA (dsRNA), and short dsRNA (less than 1 kb in length).

History note

  • 2017

In other languages

URI

http://www.yso.fi/onto/mesh/D000071457

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