Concept information
Preferred term
AlkB Enzymes
Type
-
Topical Descriptor
Broader concept
Narrower concepts
- AlkB Homolog 1, Histone H2a Dioxygenase
- AlkB Homolog 2, Alpha-Ketoglutarate-Dependent Dioxygenase
- AlkB Homolog 3, Alpha-Ketoglutarate-Dependent Dioxygenase
- AlkB Homolog 4, Lysine Demethylase
- AlkB Homolog 5, RNA Demethylase
- AlkB Homolog 8, tRNA Methyltransferase
- Alpha-Ketoglutarate-Dependent Dioxygenase FTO
Entry terms
- AlkB Homologs
- Alkylated DNA Repair Protein AlkB Homologs
- Alkylation Repair Homolog Proteins
- Alkylation Repair Homologs
Scope note
- A family of alpha- KETOGLUTARIC ACID and Fe(II)-dependent dioxygenases that are homologous to AlkB, an enzyme that repairs alkylated nucleic acids in E. coli. The mammalian homologs have diverse substrate specificities and functions that include DNA REPAIR, generating unique wobble modifications in URIDINE tRNA, demethylation of nucleotides in DNA and RNA, and demethylation of LYSINE residues on certain proteins, including ACTIN and histones (HISTONE CODE).
History note
- 2017
In other languages
-
Finnish
-
Swedish
URI
http://www.yso.fi/onto/mesh/D000071496
{{label}}
{{#each values }} {{! loop through ConceptPropertyValue objects }}
{{#if prefLabel }}
{{/if}}
{{/each}}
{{#if notation }}{{ notation }} {{/if}}{{ prefLabel }}
{{#ifDifferentLabelLang lang }} ({{ lang }}){{/ifDifferentLabelLang}}
{{#if vocabName }}
{{ vocabName }}
{{/if}}