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Enzymes and Coenzymes > Enzymes > DNA Repair Enzymes > AlkB Enzymes > AlkB Homolog 4, Lysine Demethylase
... > Enzymes and Coenzymes > Enzymes > Oxidoreductases > Oxygenases > Dioxygenases > AlkB Enzymes > AlkB Homolog 4, Lysine Demethylase
... > Enzymes and Coenzymes > Enzymes > Oxidoreductases > Oxidoreductases Acting on CH-NH Group Donors > Oxidoreductases, N-Demethylating > AlkB Homolog 4, Lysine Demethylase

Preferred term

AlkB Homolog 4, Lysine Demethylase  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Alkylated DNA Repair Protein AlkB Homolog 4
  • Alpha Ketoglutarate Dependent Dioxygenase Alkb Homolog 4
  • Alpha-Ketoglutarate-Dependent Dioxygenase Alkb Homolog 4

Scope note

  • A dioxygenase and alkylation repair homolog that mediates demethylation of ACTIN monomethylated at 'Lys-84' (K84me1). Demethylation of actin LYSINE 84 (K84me1) is required for maintaining actin and MYOSIN dynamics to support normal cleavage furrow ingression during CYTOKINESIS and CELL MIGRATION. It may also be involved in transcription regulation.

History note

  • 2017

In other languages

URI

http://www.yso.fi/onto/mesh/D000071501

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