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Enzymes and Coenzymes > Enzymes > DNA Repair Enzymes > AlkB Enzymes > Alpha-Ketoglutarate-Dependent Dioxygenase FTO
... > Enzymes and Coenzymes > Enzymes > Oxidoreductases > Oxygenases > Dioxygenases > AlkB Enzymes > Alpha-Ketoglutarate-Dependent Dioxygenase FTO
... > Enzymes and Coenzymes > Enzymes > Oxidoreductases > Oxidoreductases Acting on CH-NH Group Donors > Oxidoreductases, N-Demethylating > Alpha-Ketoglutarate-Dependent Dioxygenase FTO

Preferred term

Alpha-Ketoglutarate-Dependent Dioxygenase FTO  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • AlkB Homolog 9 Protein
  • Alpha Ketoglutarate Dependent Dioxygenase
  • Alpha-Ketoglutarate-Dependent Dioxygenase
  • Dioxygenase, Alpha-Ketoglutarate-Dependent
  • Fat Mass and Obesity Associated (FTO) Protein
  • Fat Mass and Obesity Associated Protein

Scope note

  • A dioxygenase that repairs alkylated DNA and RNA by oxidative demethylation. It has highest activity towards single-stranded RNA containing 3-methyluracil, followed by SINGLE-STRANDED DNA containing 3-methylthymine and specifically demethylates N(6)-methyladenosine (m6A) RNA, the most common internal modification of MESSENGER RNA (mRNA) in higher EUKARYOTES. It contributes to the regulation of the global metabolic rate, energy HOMEOSTASIS, as well as body fat accumulation by regulating the differentiation of ADIPOCYTES into BROWN FAT CELLS or WHITE FAT CELLS.

History note

  • 2017

In other languages

URI

http://www.yso.fi/onto/mesh/D000071516

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