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Concept information

Preferred term

Fibrillins  

Type

  • Topical Descriptor

Narrower concepts

Entry terms

  • Fibrillin

Scope note

  • A family of extracellular matrix glycoproteins that is structurally similar to LATENT TGF-BETA BINDING PROTEINS, but contain additional TGF-beta binding domains, in addition to unique domains at their N and C-terminals. Fibrillins assemble into 10-12 nm MICROFIBRILS that function in a variety of cell interactions with the EXTRACELLULAR MATRIX and developmental processes such as ELASTIC TISSUE maintenance and assembly, and the targeting of growth factors to the extracellular matrix.

History note

  • 2017; use FIBRILLIN 1985-2016

In other languages

URI

http://www.yso.fi/onto/mesh/D000071837

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