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Amino Acids, Peptides, and Proteins > Proteins > Nuclear Proteins > Chromosomal Proteins, Non-Histone > Tumor Suppressor p53-Binding Protein 1
Amino Acids, Peptides, and Proteins > Proteins > Nucleoproteins > Chromosomal Proteins, Non-Histone > Tumor Suppressor p53-Binding Protein 1
Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > Tumor Suppressor p53-Binding Protein 1

Preferred term

Tumor Suppressor p53-Binding Protein 1  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • 53BP1 Protein
  • p202 Protein
  • TP53BP1 Protein
  • Tumor Protein p53 Binding Protein, 1
  • Tumor Protein p53-Binding Protein, 1

Scope note

  • A nuclear and cytoplasmic protein that associates with KINETOCHORES and contains a C-terminal TUDOR DOMAIN. It plays a critical role in the cellular response to DNA DAMAGE and localizes to DOUBLE-STRAND DNA BREAKS. It may also function in M PHASE CELL CYCLE CHECKPOINTS and as an enhancer of TUMOR SUPPRESSOR PROTEIN P53-mediated transcriptional activation.

History note

  • 2017

In other languages

URI

http://www.yso.fi/onto/mesh/D000071857

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RDF/XML TURTLE JSON-LD Created 7/8/16, last modified 7/5/16