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Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Protein Serine-Threonine Kinases > Checkpoint Kinase 1
Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Protein Serine-Threonine Kinases > Checkpoint Kinase 1
... > Enzymes and Coenzymes > Enzymes > Transferases > Phosphotransferases > Phosphotransferases (Alcohol Group Acceptor) > Protein Kinases > Protein Serine-Threonine Kinases > Checkpoint Kinase 1

Preferred term

Checkpoint Kinase 1  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Checkpoint-1 Kinase
  • Chk1 Kinase
  • Chk1 Protein Kinase
  • Protein Kinase, Chk1

Scope note

  • A serine/threonine-specific protein kinase which is encoded by the CHEK1 gene in humans. Checkpoint kinase 1 (also known as Chk1) coordinates DNA damage response and cell cycle checkpoint response. Under these conditions, activation of Chk1 results in the initiation of cell cycle checkpoints, cell cycle arrest, DNA repair and cell death, to prevent damaged cells from progressing through the cell cycle.

History note

  • 2017 (2004)

In other languages

URI

http://www.yso.fi/onto/mesh/D000071877

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