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Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Membrane Glycoproteins > AC133 Antigen
Carbohydrates > Glycoconjugates > Glycoproteins > Membrane Glycoproteins > AC133 Antigen
Amino Acids, Peptides, and Proteins > Proteins > Glycoproteins > Membrane Glycoproteins > AC133 Antigen

Preferred term

AC133 Antigen  

Type

  • Topical Descriptor

Broader concept

Related concepts

Entry terms

  • AC133 1 Antigen
  • AC133-1 Antigen
  • Antigen, AC133-1
  • Antigen, CD133
  • CD133 Antigen
  • Fudenine
  • Prominin
  • Prominin 1
  • Prominin-1
  • Prominin Like PROML1
  • Prominin-Like PROML1
  • PROML1

Scope note

  • A member of the prominin family, AC133 Antigen is a 5-transmembrane antigen occurring as several isoforms produced by alternative splicing which are processed into mature forms. In humans, it is expressed as a subset of CD34 (bright) human hematopoietic stem cells and CD34 positive leukemias. Functionally, it is associated with roles in cell differentiation, proliferation, and apoptosis. Specifically, it regulates the organization of apical plasma membrane in epithelial cells, disk morphogenesis during early retinal development, MAPK and Akt signaling pathways, and in cholesterol metabolism.

History note

  • 2017(1998)

In other languages

URI

http://www.yso.fi/onto/mesh/D000071916

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