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Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > Adaptor Proteins, Signal Transducing > Kelch-Like ECH-Associated Protein 1
Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Adaptor Proteins, Signal Transducing > Kelch-Like ECH-Associated Protein 1
Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Adaptor Proteins, Signal Transducing > Kelch-Like ECH-Associated Protein 1

Preferred term

Kelch-Like ECH-Associated Protein 1  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • KEAP 1 Protein
  • KEAP-1 Protein
  • KEAP1 Protein

Scope note

  • An adaptor protein characterized by an N-terminal BTB-POZ DOMAIN and six KELCH REPEATS that functions as a substrate for the E3 UBIQUITIN LIGASE complex. It negatively-regulates NF-E2-RELATED FACTOR 2 by targeting it for ubiquitination and degradation by the PROTEASOME. It also represses genes regulated by ANTIOXIDANT RESPONSE ELEMENTS.

History note

  • 2017

In other languages

URI

http://www.yso.fi/onto/mesh/D000072019

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RDF/XML TURTLE JSON-LD Created 7/8/16, last modified 5/27/16