Skip to main content

Medical Subject Headings

Search from vocabulary

Content language

Concept information

... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Receptors, Cell Surface > Patched Receptors > Patched-1 Receptor
... > Amino Acids, Peptides, and Proteins > Proteins > Neoplasm Proteins > Tumor Suppressor Proteins > Patched Receptors > Patched-1 Receptor

Preferred term

Patched-1 Receptor  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Patched 1 Protein
  • Patched-1 Protein
  • Patched Homolog 1
  • Patched Homolog-1
  • Patched Receptor 1
  • Patched Receptor-1
  • PTCH1 Protein
  • Receptor-1, Patched

Scope note

  • A patched receptor for several HEDGEHOG PROTEINS that associates with the SMOOTHENED RECEPTOR to modulate hedgehog signaling. It is also a TUMOR SUPPRESSOR PROTEIN; mutations in the patched-1 gene are associated with BASAL CELL NEVUS SYNDROME; SQUAMOUS CELL CARCNIOMA of the ESOPHAGUS; trichoepitheliomas, and CARCINOMA, TRANSITIONAL CELL of the URINARY BLADDER.

History note

  • 2017 (1996)

In other languages

URI

http://www.yso.fi/onto/mesh/D000072081

Download this concept:

RDF/XML TURTLE JSON-LD Created 7/8/16, last modified 6/25/24