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... > Enzymes and Coenzymes > Enzymes > Hydrolases > Esterases > Phosphoric Monoester Hydrolases > Phosphoinositide Phosphatases > Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases

Preferred term

Phosphatidylinositol-3,4,5-Trisphosphate 5-Phosphatases  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Phosphatases, SHIP
  • SHIP Phosphatases
  • Src Homology 2 Domain Containing Inositol Phosphatases
  • Src Homology 2 Domain-Containing Inositol Phosphatases

Scope note

  • Phosphoinositide phosphatases that catalyze the dephosphorylation (hydrolysis) of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P(3)) to produce PtdIns(3,4)P(2), which negatively regulates the PI3K ( 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES) pathways. They contain an SH2 DOMAIN and STERILE ALPHA MOTIF and have important functions in regulating the immune response and other cellular processes in vertebrates.

History note

  • 2017

In other languages

URI

http://www.yso.fi/onto/mesh/D000072183

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