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Amino Acids, Peptides, and Proteins > Proteins > Glycoproteins > ADAM Proteins > ADAM17 Protein
Carbohydrates > Glycoconjugates > Glycoproteins > ADAM Proteins > ADAM17 Protein
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Endopeptidases > Metalloendopeptidases > ADAM Proteins > ADAM17 Protein
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Metalloproteases > Metalloendopeptidases > ADAM Proteins > ADAM17 Protein

Preferred term

ADAM17 Protein  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • ADAM-17
  • ADAM 17 Protein
  • ADAM-17 Protein
  • Antigen, CD156b
  • CD156b Antigen
  • Convertase, TNF-alpha
  • Disintegrin and Metalloproteinase Domain Containing Protein 17
  • Disintegrin and Metalloproteinase Domain-Containing Protein 17
  • TACA (Enzyme)
  • TACE (Enzyme)
  • TNF alpha Convertase
  • TNF-alpha Convertase
  • TNF alpha Converting Enzyme
  • TNF-alpha Converting Enzyme
  • Tumor Necrosis Factor Alpha Convertase
  • Tumor Necrosis Factor-alpha Convertase
  • Tumor Necrosis Factor alpha Converting Enzyme
  • Tumor Necrosis Factor-alpha Converting Enzyme

Scope note

  • A disintegrin and metalloproteinase domain-containing protein that cleaves the membrane-bound precursor of TUMOR NECROSIS FACTOR-ALPHA to its mature form. It cleaves several other CELL SURFACE PROTEINS, including INTERLEUKIN-1 RECEPTOR TYPE II; TRANSFORMING GROWTH FACTOR ALPHA; L-SELECTIN; MUCIN-1; and AMYLOID BETA-PROTEIN PRECURSOR. It can also function as an activator of the Notch signaling pathway by mediating the cleavage of NOTCH RECEPTORS.

History note

  • 2017 (1996)

In other languages

URI

http://www.yso.fi/onto/mesh/D000072198

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