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Concept information

Preferred term

ERG1 Potassium Channel  

Type

  • Topical Descriptor

Entry terms

  • Ether A Go Go Related Potassium Channel 1
  • Ether-A-Go-Go-Related Potassium Channel 1
  • Potassium Voltage-Gated Channel, Subfamily H, Member 2

Scope note

  • One of three members of the ether-a-go-go (EAG) POTASSIUM CHANNELS gene family comprising ether-a-go-go (eag), eag-like (elk) and eag-related (erg) subfamilies. Ether-a-go-go-related gene 1 (ERG1) also known as KCNH2, encodes the pore-forming subunit of a rapidly activating-delayed rectifier potassium channel that plays an essential role in the final repolarization of ventricular action potential. Loss-of-function mutations in human hERG1 is associated with life-threatening ARRHYTHMIA.

History note

  • 2017 (2001)

In other languages

URI

http://www.yso.fi/onto/mesh/D000072237

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