Skip to main content

Medical Subject Headings

Search from vocabulary

Content language

Concept information

Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > Adaptor Proteins, Signal Transducing > Dishevelled Proteins
Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Adaptor Proteins, Signal Transducing > Dishevelled Proteins
Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Adaptor Proteins, Signal Transducing > Dishevelled Proteins

Preferred term

Dishevelled Proteins  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Dishevelled Protein

Scope note

  • A family of proteins that are key components of the WNT SIGNALING PATHWAY, where they function downstream of FRIZZLED RECEPTORS. They contain an N-terminal dishevelled-AXIN PROTEIN (DIX) domain, which mediates oligomerization; a central PDZ DOMAIN which binds to the frizzled receptor; and a C-terminal DEP domain which facilitates binding to the CELL MEMBRANE. Dishevelled proteins have important functions in CELL DIFFERENTIATION and establishing CELL POLARITY.

History note

  • 2017 (1994)

In other languages

URI

http://www.yso.fi/onto/mesh/D000072261

Download this concept:

RDF/XML TURTLE JSON-LD Created 7/8/16, last modified 5/24/17