Concept information
Preferred term
P-type ATPases
Type
-
Topical Descriptor
Broader concept
Narrower concepts
Entry terms
- Adenosine Triphosphatase, P-type
- Adenosine Triphosphatases, Phosphorylation-type
- Adenosine Triphosphatases, P-type
- ATPase, E1-E2
- Atpase, P Type
- ATPase, P-type
- ATPases, E1-E2
- ATPases, Phosphorylation-type
- E1 E2 ATPase
- E1-E2 ATPase
- E1 E2 ATPases
- E1-E2 ATPases
- Phosphorylation type Adenosine Triphosphatases
- Phosphorylation-type Adenosine Triphosphatases
- Phosphorylation type ATPases
- Phosphorylation-type ATPases
- P type Adenosine Triphosphatase
- P-type Adenosine Triphosphatase
- P type Adenosine Triphosphatases
- P-type Adenosine Triphosphatases
- P Type Atpase
- P-type ATPase
- Triphosphatase, P-type Adenosine
- Triphosphatases, Phosphorylation-type Adenosine
- Triphosphatases, P-type Adenosine
- Type Atpase, P
Scope note
- A highly conserved family of ATPases that facilitate the transport of lipids and cations across the plasma membrane. Structurally, they are elongated ALPHA-HELICES constituting five functionally distinct domains: three cytoplasmic domains A, N, and P which contain the catalytic sites, and two transmembrane domains. The N domain phosphorylates the P-domain at an invariant ASPARTATE residue, which, in turn, is dephosphorylated by the A domain. The phosphorylation and dephosphorylation cycles drive conformational changes in the protein between two states (E1 and E2), which allow the substrate to access the other side of the membrane.
History note
- 2018
In other languages
-
Finnish
URI
http://www.yso.fi/onto/mesh/D000073779
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