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... > Enzymes and Coenzymes > Enzymes > Hydrolases > Amidohydrolases > Histone Deacetylases > Histone Deacetylase 6

Preferred term

Histone Deacetylase 6  

Type

  • Topical Descriptor

Broader concept

Scope note

  • A class II histone deacetylase that removes acetyl groups from N-terminal LYSINES of HISTONE H2A; HISTONE H2B; HISTONE H3; and HISTONE H4. It plays a critical role in EPIGENETIC REPRESSION and regulation of GENETIC TRANSCRIPTION, as well as CELL MOTILITY through deacetylation of TUBULIN. It also targets misfolded proteins for clearance by AUTOPHAGY when MOLECULAR CHAPERONE-mediated folding is overwhelmed.

History note

  • 2018

In other languages

URI

http://www.yso.fi/onto/mesh/D000073864

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