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Amino Acids, Peptides, and Proteins > Proteins > Cell Cycle Proteins > F-Box-WD Repeat-Containing Protein 7
Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > F-Box Proteins > F-Box-WD Repeat-Containing Protein 7
... > Enzymes and Coenzymes > Enzymes > Ligases > Ubiquitin-Protein Ligase Complexes > Ubiquitin-Protein Ligases > SKP Cullin F-Box Protein Ligases > F-Box-WD Repeat-Containing Protein 7

Preferred term

F-Box-WD Repeat-Containing Protein 7  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • F Box and WD 40 Domain Containing Protein 7
  • F-Box and WD-40 Domain-Containing Protein 7
  • FBXW7 Protein

Scope note

  • A component of SCF(FBW7) UBIQUITIN LIGASE that contains an F-box motif and multiple WD REPEATS. It recognizes and binds phosphorylated signals in several proteins involved in CELL PROLIFERATION and targets them to the SCF complex for UBIQUITINATION. Targets include CYCLIN E; PROTO-ONCOGENE PROTEINS C-JUN; PROTO-ONCOGENE PROTEINS C-MYC; and JNK MITOGEN-ACTIVATED PROTEIN KINASES.

History note

  • 2018

In other languages

URI

http://www.yso.fi/onto/mesh/D000073979

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RDF/XML TURTLE JSON-LD Created 7/11/17, last modified 2/27/17