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Biological Factors > Intercellular Signaling Peptides and Proteins > Cytokines > Tumor Necrosis Factors > Cytokine TWEAK
... > Amino Acids, Peptides, and Proteins > Proteins > Intercellular Signaling Peptides and Proteins > Cytokines > Tumor Necrosis Factors > Cytokine TWEAK
... > Amino Acids, Peptides, and Proteins > Peptides > Intercellular Signaling Peptides and Proteins > Cytokines > Tumor Necrosis Factors > Cytokine TWEAK

Preferred term

Cytokine TWEAK  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Apo3 Ligand
  • Cytokine, TWEAK
  • Ligand, Apo3
  • TNF Related Weak Inducer of Apoptosis
  • TNF-Related Weak Inducer of Apoptosis
  • Tumor Necrosis Factor Ligand Superfamily Member 12
  • TWEAK Cytokine

Scope note

  • A proteolytically-cleaved membrane glycoprotein and member of the TNF superfamily that is highly expressed in a variety of tissues including heart, pancreas, brain, and peripheral blood lymphocytes. The secreted extracellular form is a weak inducer of APOPTOSIS for some cell types and a ligand for the FN14 RECEPTOR. It mediates activation of NF-KAPPA-B and promotes ANGIOGENESIS and proliferation of ENDOTHELIAL CELLS, as well as expression of cytokines involved in INFLAMMATION.

History note

  • 2018

In other languages

URI

http://www.yso.fi/onto/mesh/D000074049

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