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... > Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Protein Serine-Threonine Kinases > Protein Kinase C > Protein Kinase C-theta
... > Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Protein Serine-Threonine Kinases > Protein Kinase C > Protein Kinase C-theta
... > Enzymes and Coenzymes > Enzymes > Transferases > Phosphotransferases > Phosphotransferases (Alcohol Group Acceptor) > Protein Kinases > Protein Serine-Threonine Kinases > Protein Kinase C > Protein Kinase C-theta

Preferred term

Protein Kinase C-theta  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • PKC theta
  • PKC-theta
  • PRKCQ
  • Protein Kinase C theta
  • Protein Kinase C, theta

Scope note

  • A calcium-independent, phospholipid- and diacylglycerol-dependent, protein kinase C subtype that contains an N-terminal C2 DOMAIN and two diacylglycerol-binding ZINC FINGERS. It is expressed primarily by T-LYMPHOCYTES and localizes to IMMUNOLOGICAL SYNAPSES where it regulates downstream signaling for the activation, proliferation, and survival of mature T-cells. It plays a critical role in allergic, autoimmune, and alloimmune responses of TH2 CELLS and TH17 CELLS.

History note

  • 2018

In other languages

URI

http://www.yso.fi/onto/mesh/D000074121

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