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... > Enzymes and Coenzymes > Enzymes > Hydrolases > Acid Anhydride Hydrolases > Adenosine Triphosphatases > ATPases Associated with Diverse Cellular Activities > Spastin
... > Amino Acids, Peptides, and Proteins > Proteins > Carrier Proteins > AAA Proteins > ATPases Associated with Diverse Cellular Activities > Spastin
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Acid Anhydride Hydrolases > AAA Proteins > ATPases Associated with Diverse Cellular Activities > Spastin
Amino Acids, Peptides, and Proteins > Proteins > Nerve Tissue Proteins > Microtubule-Associated Proteins > Spastin
... > Chemical Actions and Uses > Specialty Uses of Chemicals > Biomedical and Dental Materials > Polymers > Biopolymers > Microtubule Proteins > Microtubule-Associated Proteins > Spastin
... > Technology, Industry, and Agriculture > Manufactured Materials > Biomedical and Dental Materials > Polymers > Biopolymers > Microtubule Proteins > Microtubule-Associated Proteins > Spastin
... > Macromolecular Substances > Polymers > Biopolymers > Microtubule Proteins > Microtubule-Associated Proteins > Spastin
... > Amino Acids, Peptides, and Proteins > Proteins > Cytoskeletal Proteins > Microtubule Proteins > Microtubule-Associated Proteins > Spastin

Preferred term

Spastin  

Type

  • Topical Descriptor

Broader concept

Related concepts

Entry terms

  • Spastic Paraplegia 4 Protein

Scope note

  • An AAA ATPase that binds and severs MICROTUBULES. It specifically recognizes and cuts polyglutamylated microtubules with short polyglutamate tails to promote reorganization of cellular microtubule arrays and the release of microtubules from the CENTROSOME following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in AXONS; SPINDLE APPARATUS; and CILIA. Mutations in the spastin gene (SPAST) are associated with type 4 of HEREDITARY SPASTIC PARAPLEGIA.

History note

  • 2018

In other languages

URI

http://www.yso.fi/onto/mesh/D000074181

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