Concept information
...
Membrane Transport Proteins
Ion Channels
Transient Receptor Potential Channels
TRPC Cation Channels
Preferred term
TRPC6 Cation Channel
Type
-
Topical Descriptor
Broader concept
Entry terms
- Transient Receptor Potential Cation Channel Subfamily C, Member 6
- TRPC6
Scope note
- A non-selective, calcium permeant TRPC cation channel that contains four ANKYRIN REPEATS and is activated by DIACYLGLYCEROL independently of PROTEIN KINASE C. It is expressed in placenta, lung, spleen, ovary and the small intestine, as well as by PODOCYTES in the kidney glomerulus. Mutations in the TRPC6 gene are associated with FOCAL SEGMENTAL GLOMERULOSCLEROSIS type 2.
History note
- 2018
In other languages
-
Finnish
URI
http://www.yso.fi/onto/mesh/D000074287
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