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Concept information

Preferred term

TRPC6 Cation Channel  

Type

  • Topical Descriptor

Entry terms

  • Transient Receptor Potential Cation Channel Subfamily C, Member 6
  • TRPC6

Scope note

  • A non-selective, calcium permeant TRPC cation channel that contains four ANKYRIN REPEATS and is activated by DIACYLGLYCEROL independently of PROTEIN KINASE C. It is expressed in placenta, lung, spleen, ovary and the small intestine, as well as by PODOCYTES in the kidney glomerulus. Mutations in the TRPC6 gene are associated with FOCAL SEGMENTAL GLOMERULOSCLEROSIS type 2.

History note

  • 2018

In other languages

URI

http://www.yso.fi/onto/mesh/D000074287

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