Concept information
Preferred term
High-Temperature Requirement A Serine Peptidase 1
Type
-
Topical Descriptor
Broader concept
Entry terms
- HTRA1, Serine Protease
- Protease HTRA1, Serine
- Serine Protease HTRA1
Scope note
- A secreted serine protease that contains a Kazal domain-like region and a C-terminal PDZ domain. It has a broad range of targets that include EXTRACELLULAR MATRIX PROTEINS; PROTEOGLYCANS; and INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS. Mutations in the HTRA1 gene are associated with AGE-RELATED MACULAR DEGENERATION 7 and Cerebral Autosomal Recessive Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CARASIL).
History note
- 2018
In other languages
-
Finnish
-
korkeaa lämpötilaa vaativa seriinin peptidaasi A 1
URI
http://www.yso.fi/onto/mesh/D000074289
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