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Amino Acids, Peptides, and Proteins > Proteins > Transcription Factors > Kruppel-Like Transcription Factors > Zinc Finger Protein Gli3
Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > Kruppel-Like Transcription Factors > Zinc Finger Protein Gli3
Amino Acids, Peptides, and Proteins > Proteins > Transcription Factors > Repressor Proteins > Zinc Finger Protein Gli3
Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > Repressor Proteins > Zinc Finger Protein Gli3

Preferred term

Zinc Finger Protein Gli3  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • GLI Kruppel Family Member 3 Protein
  • GLI-Kruppel Family Member 3 Protein
  • Glioma Associated Oncogene Family Zinc Finger 3 Protein
  • Glioma-Associated Oncogene Family Zinc Finger 3 Protein

Scope note

  • A zinc finger transcription factor that contains five CYS2-HIS2 ZINC FINGERS and binds to the GLI consensus sequence 5'-GGGTGGTC-3'. The full-length protein functions as a transcriptional activator whereas the truncated C-terminal form functions as a transcriptional repressor of the Sonic Hedgehog (Shh) signaling pathway; a balance between these two forms is critical for limb and digit development. GLI3 also plays a critical role in the differentiation and proliferation of CHONDROCYTES.

History note

  • 2018

In other languages

URI

http://www.yso.fi/onto/mesh/D000074290

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