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... > Enzymes and Coenzymes > Enzymes > Transferases > Acyltransferases > Acetyltransferases > Lysine Acetyltransferases > Histone Acetyltransferases > Lysine Acetyltransferase 5

Preferred term

Lysine Acetyltransferase 5  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • HIV 1 Tat Interactive Protein Tip60
  • HIV-1-Tat Interactive Protein Tip60
  • HTATIP
  • KAT5 (TIP60) Protein

Scope note

  • A catalytic subunit of the NuA4 histone acetyltransferase complex that functions in transcriptional activation of genes by acetylation of nucleosomal HISTONES H4 and H2A, altering nucleosome-DNA interactions and interaction of the modified histones with other activating transcription factors. It may control gene expression changes associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest; CELL AGING; APOPTOSIS; and DNA REPAIR. It is polyubiquitinated and degraded during HIV-1 infection through its interaction with the viral TAT PROTEIN.

History note

  • 2018

In other languages

URI

http://www.yso.fi/onto/mesh/D000074443

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