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... > Chemical Phenomena > Biochemical Phenomena > Molecular Structure > Molecular Conformation > Protein Conformation > Protein Structural Elements > Protein Domains > PR-SET Domains
... > Chemical Phenomena > Biochemical Phenomena > Molecular Structure > Molecular Conformation > Protein Conformation > Protein Structure, Tertiary > Protein Domains > PR-SET Domains

Preferred term

PR-SET Domains  

Type

  • Topical Descriptor

Broader concept

Related concepts

Entry terms

  • Domain, PR
  • Domain, SET
  • Domains, PR
  • Domains, SET
  • PR Domain
  • PR Domains
  • SET Domain
  • SET Domains

Scope note

  • Highly conserved protein domains of approximately 130 to 140 amino acids. The SET domain was first identified in the Drosophila proteins (S)u(var)3-9, (E)nhancer-of-zeste and (T)rithorax and occurs in other proteins with a variety of functions, including histone-lysine N-methyltransferases. Structurally, it consists of BETA-SHEETS interspersed among loops and turns that result in an "L" shape. The most conserved motifs are a stretch at the C-terminal that contains a strictly conserved tyrosine residue and an adjacent loop that the C-terminal segment passes through to form a "knot". These motifs and especially the tyrosine residue are essential for S-ADENOSYLMETHIONINE binding and catalysis. The PR domain has high homology to the catalytic region of the SET domain and occurs at the N-terminal of PRDM proteins such as PRDM1 PROTEIN.

History note

  • 2018

In other languages

  • PR-SET-domeenit

    Finnish

  • PR-SET-proteiinidomeenit
  • PR-SET-proteiinirakenteet
  • PR-SET-rakenteet proteiinissa
  • PR-SET-domäner

    Swedish

  • PR-domän
  • SET-domän

URI

http://www.yso.fi/onto/mesh/D000074463

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RDF/XML TURTLE JSON-LD Created 7/11/17, last modified 4/5/17