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Amino Acids, Peptides, and Proteins > Proteins > Transcription Factors > Thyroid Nuclear Factor 1
Amino Acids, Peptides, and Proteins > Proteins > Nuclear Proteins > Thyroid Nuclear Factor 1
Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > Homeodomain Proteins > Thyroid Nuclear Factor 1

Preferred term

Thyroid Nuclear Factor 1  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Enhancer-Binding Protein, Thyroid-Specific
  • Homeobox Protein Nkx 2.1
  • Homeobox Protein Nkx-2.1
  • NK2 Homeobox 1 Protein
  • Nkx-2.1, Homeobox Protein
  • Thyroid Specific Enhancer Binding Protein
  • Thyroid-Specific Enhancer-Binding Protein
  • Thyroid Transcription Factor 1
  • TITF 1 Protein
  • TITF-1 Protein
  • TITF1 Protein
  • TTF 1 Thyroid Nuclear Factor
  • TTF-1 Thyroid Nuclear Factor

Scope note

  • A homeobox protein and transcription factor that localizes to the cell nucleus where it activates expression of thyroid specific genes such as THYROGLOBULIN and the THYROTROPIN RECEPTOR. It is critical for maintaining thyroid tissue in a differentiated state and also plays a role in lung development. Mutations in the NKX2-1 gene are associated with CHOREA, BENIGN HEREDITARY.

History note

  • 2018 (1990)

In other languages

URI

http://www.yso.fi/onto/mesh/D000074482

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