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Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Vesicular Transport Proteins > Dysbindin
Amino Acids, Peptides, and Proteins > Proteins > Nerve Tissue Proteins > Dysbindin
Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Dystrophin-Associated Proteins > Dysbindin
Amino Acids, Peptides, and Proteins > Proteins > Cytoskeletal Proteins > Dystrophin-Associated Proteins > Dysbindin
... > Amino Acids, Peptides, and Proteins > Proteins > Contractile Proteins > Muscle Proteins > Dystrophin-Associated Proteins > Dysbindin

Preferred term

Dysbindin  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • DTNBP1 Protein
  • Dysbindin 1
  • Dysbindin-1
  • Dystrobrevin Binding Protein 1
  • Hermansky Pudlak Syndrome 7 Protein
  • Hermansky-Pudlak Syndrome 7 Protein

Scope note

  • A dystrophin-associated protein and component of the Biogenesis of Lysosomal Organelles Complex-1 (BLOC-1 complex) which is essential for the formation of LYSOSOME - derived organelles such as platelet dense granules and MELANOSOMES. DTNBP1 is expressed primarily in the brain and neurons, where it functions with ADAPTOR PROTEIN COMPLEX 3 to transport membrane proteins to NEURITES and nerve terminals. It also regulates the release of neurotransmitters, transport of synaptic vesicles, and localization of DOPAMINE D2 RECEPTORS. Mutations in the DTNBP1 gene are associated with Type 7 HERMANSKY-PUDLAK SYNDROME and SCHIZOPHRENIA.

History note

  • 2018

In other languages

URI

http://www.yso.fi/onto/mesh/D000074765

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