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... > Amino Acids, Peptides, and Proteins > Proteins > Transcription Factors > Winged-Helix Transcription Factors > Forkhead Transcription Factors > Forkhead Box Protein L2
... > Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > Winged-Helix Transcription Factors > Forkhead Transcription Factors > Forkhead Box Protein L2

Preferred term

Forkhead Box Protein L2  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Forkhead Box L2 Protein
  • FOXL2 Protein

Scope note

  • A forkhead box transcription factor that is expressed in the developing eyelid and during very early development of the gonad, prior to sex determination. It is essential for development of the ovary and inhibits SOX9 TRANSCRIPTION FACTOR to prevent differentiation to testes. It also induces APOPTOSIS in ovarian cells. Mutations in the FOXL2 gene are associated with BLEPHAROPHIMOSIS; Ptosis, and Epicanthus inversus (BPES with ovarian failure).

History note

  • 2018

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URI

http://www.yso.fi/onto/mesh/D000074842

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RDF/XML TURTLE JSON-LD Created 7/11/17, last modified 5/22/17