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Amino Acids, Peptides, and Proteins > Proteins > Mitochondrial Proteins > High-Temperature Requirement A Serine Peptidase 2
Amino Acids, Peptides, and Proteins > Proteins > Parkinson Disease Associated Proteins > High-Temperature Requirement A Serine Peptidase 2
Amino Acids, Peptides, and Proteins > Proteins > Intracellular Signaling Peptides and Proteins > Apoptosis Regulatory Proteins > High-Temperature Requirement A Serine Peptidase 2
Amino Acids, Peptides, and Proteins > Peptides > Intracellular Signaling Peptides and Proteins > Apoptosis Regulatory Proteins > High-Temperature Requirement A Serine Peptidase 2
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Endopeptidases > Serine Endopeptidases > High-Temperature Requirement A Serine Peptidase 2
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Serine Proteases > Serine Endopeptidases > High-Temperature Requirement A Serine Peptidase 2

Preferred term

High-Temperature Requirement A Serine Peptidase 2  

Type

  • Topical Descriptor

Broader concept

Related concepts

Entry terms

  • HtrA2 Protease
  • HTRA2, Serine Protease
  • HtrA Serine Peptidase 2
  • Omi Serine Protease
  • Omi, Serine Protease
  • Protease, HtrA2
  • Protease HTRA2, Serine
  • Protease Omi, Serine
  • Protease, Omi Serine
  • Serine Protease HTRA2
  • Serine Protease Omi
  • Serine Protease, Omi

Scope note

  • A serine peptidase that contains a C-terminal PDZ domain. It localizes to the mitochondrial membrane and intermembrane space, translocating to the cytoplasm following APOPTOSIS stimuli, such as UV irradiation; it promotes cell death by binding to and inhibiting INHIBITOR OF APOPTOSIS PROTEINS, resulting in an increase in activity of CASPASES. Mutations in the HTRA2 gene are associated with Type 13 PARKINSON DISEASE.

History note

  • 2018 (2000)

In other languages

URI

http://www.yso.fi/onto/mesh/D000074923

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