Skip to main content

Medical Subject Headings

Search from vocabulary

Content language

Concept information

Amino Acids, Peptides, and Proteins > Proteins > Transcription Factors > Pre-B-Cell Leukemia Transcription Factor 1
Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > Homeodomain Proteins > Pre-B-Cell Leukemia Transcription Factor 1
... > Amino Acids, Peptides, and Proteins > Proteins > Neoplasm Proteins > Oncogene Proteins > Proto-Oncogene Proteins > Pre-B-Cell Leukemia Transcription Factor 1

Preferred term

Pre-B-Cell Leukemia Transcription Factor 1  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Homeobox Protein, PBX1
  • PBX1 Homeobox Protein
  • Pre B Cell Leukemia Homeobox 1 Protein
  • Pre-B-Cell Leukemia Homeobox 1 Protein

Scope note

  • A TALE-type homeodomain protein and transcription factor that binds the DNA sequence 5'-ATCAATCAA-3'. It forms a heterodimer with MEIS1 TRANSCRIPTION FACTOR and functions as a transcriptional activator of HOMEOBOX PROTEIN NKX-2.5 and ELONGIN A, and as a transcriptional repressor of CDKN2B PROTEIN, in the regulation of developmental and morphogenetic processes such as spleen and limb development. Chromosome translocations involving the PBX1 and TCF3 genes occur in cases of pre-B-cell ACUTE LYMPHOID LEUKEMIA.

History note

  • 2018

In other languages

  • B-soluisen prolymfosyyttileukemian transkriptiotekijä 1

    Finnish

  • B-soluiseen prolymfosyyttileukemiaan liittyvä transkriptiotekijä 1
  • pro-B-lymfosyyttileukemiatranskriptiotekijä 1
  • transkriptiotekijä 1 B-soluisessa prolymfosyyttileukemiassa
  • transkriptiotekijä 1 pro-B-lymfosyyttileukemiassa

URI

http://www.yso.fi/onto/mesh/D000075062

Download this concept:

RDF/XML TURTLE JSON-LD Created 7/11/17, last modified 5/22/17