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... > Amino Acids, Peptides, and Proteins > Proteins > Neoplasm Proteins > Oncogene Proteins > Proto-Oncogene Proteins > RUNX1 Translocation Partner 1 Protein
... > Amino Acids, Peptides, and Proteins > Proteins > Transcription Factors > Repressor Proteins > Co-Repressor Proteins > RUNX1 Translocation Partner 1 Protein
... > Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > Repressor Proteins > Co-Repressor Proteins > RUNX1 Translocation Partner 1 Protein

Preferred term

RUNX1 Translocation Partner 1 Protein  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Eight Twenty One Protein
  • RUNX1T1 Protein

Scope note

  • A transcriptional co-repressor that contains a MYND-type zinc finger (MYND DOMAIN) at its C-terminal and functions as a homo-oligomer. It associates with DNA-binding transcription factors, other repressor proteins, and HISTONE ACETYLTRANSFERASES to repress expression of genes involved in cell growth and differentiation such as MATRIX METALLOPROTEINASE 7 and TCF12. A CHROMOSOMAL TRANSLOCATION involving the RUNX1T1 and CORE BINDING FACTOR ALPHA 2 SUBUNIT (RUNX1) genes frequently occurs in cells of leukemia patients; the resulting fusion protein (AML1-ETO or RUNX1-RUNX1T1) plays a critical role in leukemogenesis.

History note

  • 2018

In other languages

URI

http://www.yso.fi/onto/mesh/D000075142

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