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Macromolecular Substances > Multiprotein Complexes > COP9 Signalosome Complex
... > Enzymes and Coenzymes > Enzymes > Hydrolases > Peptide Hydrolases > Endopeptidases > Ubiquitin-Specific Proteases > COP9 Signalosome Complex
Enzymes and Coenzymes > Enzymes > Deubiquitinating Enzymes > Ubiquitin-Specific Proteases > COP9 Signalosome Complex

Preferred term

COP9 Signalosome Complex  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Constitutive Photomorphogenesis 9 Signalosome
  • Constitutive Photomorphogenesis 9 Signalsome
  • COP9 Signalosome (CSN)
  • COP9 Signalsome
  • Signalsome, COP9

Scope note

  • A multiprotein complex that functions as a peptide hydrolase, or isopeptidase to cleave NEDD8 PROTEIN from the CULLIN and UBIQUITIN-PROTEIN LIGASES, controlling the activity of the ligases. It is highly conserved in eukaryotes and typically consists of 8 subunits (CSN 1-8 proteins). The COP9 signalosome was originally identified in plants, where it controls gene transcription in response to light.

History note

  • 2018 (1995); for COP9 SIGNALOSOME SUBUNIT 3 use SIGNALOSOME SUBUNIT 3 1998-2017

In other languages

URI

http://www.yso.fi/onto/mesh/D000075686

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