Concept information
Preferred term
NEDD8 Protein
Type
-
Topical Descriptor
Broader concept
Entry terms
- NEDD 8 Protein
- NEDD-8 Protein
- NEDD8, Ubiquitin-like Protein
- Neural Precursor Cell Expressed Developmentally Down Regulated Protein 8
- Neural Precursor Cell Expressed Developmentally Down-Regulated Protein 8
- Ubiquitin like Protein NEDD8
- Ubiquitin-like Protein NEDD8
Scope note
- A ubiquitin-like protein that functions in CELL CYCLE regulation and embryogenesis. It is attached covalently to its substrates following activation by the UBIQUITIN-ACTIVATING ENZYME E1-UBA3 enzyme complex. NEDD8 attaches to CULLINS, activating their E3 UBIQUITIN LIGASE activity, to promote polyubiquitination and degradation of CYCLINS and regulatory proteins
History note
- 2018
In other languages
-
Finnish
URI
http://www.yso.fi/onto/mesh/D000075687
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