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... > Enzymes and Coenzymes > Enzymes > Ligases > Ubiquitin-Protein Ligase Complexes > Ubiquitin-Protein Ligases > Nedd4 Ubiquitin Protein Ligases
... > Amino Acids, Peptides, and Proteins > Proteins > Membrane Proteins > Vesicular Transport Proteins > Endosomal Sorting Complexes Required for Transport > Nedd4 Ubiquitin Protein Ligases
Macromolecular Substances > Multiprotein Complexes > Endosomal Sorting Complexes Required for Transport > Nedd4 Ubiquitin Protein Ligases

Preferred term

Nedd4 Ubiquitin Protein Ligases  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • Nedd4 Proteins
  • Neuronal Precursor Cell Expressed Developmentally Down Regulated 4 Ligase
  • Neuronal Precursor Cell-Expressed Developmentally Down-Regulated 4 Ligase

Scope note

  • E3 ubiquitin ligases that consist of four WW DOMAINS. They accept UBIQUITIN from E2 UBIQUITIN-CONJUGATING ENZYME as a thioester via their C-terminal HECT domains and transfer it specifically to the 63rd LYSINE residue (Lys-63) of target proteins. NEDD4 targets include many proteins and receptors with important functions for cell growth and homeostasis such as VEGFR-2; FGFR1 TYROSINE KINASE; and ERBB-4 RECEPTOR. They play a critical role in the internalization of these receptors, their degradation by LYSOSOMES, and also function as part of the ESCRT complex in VIRUS RELEASE.

History note

  • 2018 (1996)

In other languages

URI

http://www.yso.fi/onto/mesh/D000075702

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