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Amino Acids, Peptides, and Proteins > Proteins > Transcription Factors > Kruppel-Like Transcription Factors > Promyelocytic Leukemia Zinc Finger Protein
Amino Acids, Peptides, and Proteins > Proteins > DNA-Binding Proteins > Kruppel-Like Transcription Factors > Promyelocytic Leukemia Zinc Finger Protein

Preferred term

Promyelocytic Leukemia Zinc Finger Protein  

Type

  • Topical Descriptor

Broader concept

Entry terms

  • PLZF Protein
  • Promyelocytic Leukaemia Zinc Finger Protein
  • ZBTB16 Protein
  • Zinc Finger and BTB Domain Containing 16 Protein

Scope note

  • A Kruppel-type transcription factor consisting of an N-terminal BTB DOMAIN and nine CYS2-HIS2 ZINC FINGERS. It localizes to the nucleus and regulates cell cycle progression and gene expression for tissue development and homeostasis; it may also function as an epigenetic regulator through its interactions with HISTONE DEACETYLASE. Genetic rearrangements involving the ZBTB16 gene are associated with ACUTE PROMYELOCYTIC LEUKEMIA.

History note

  • 2018

In other languages

URI

http://www.yso.fi/onto/mesh/D000075722

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RDF/XML TURTLE JSON-LD Created 7/11/17, last modified 5/21/18